Determination of Branched [beta]-Cyclodextrin-Prostaglandin Complexes Using Electrospray Ionization Mass Spectrometry

Determination of Branched [beta]-Cyclodextrin-Prostaglandin Complexes Using Electrospray Ionization Mass Spectrometry

Mass spectral measurements by electrospray ionization mass spectrometry (ESI-MS) detected the ions of β-cyclodextrin (βCD) or branched βCDs (glucosyl-, galactosyl-, mannosyl- and maltosyl-βCD)-prostaglandins (PGs: PGA2, PGD2, PGE1, PGE2, PGF2α and PGJ2) complexes, i.e., βCD-PG complexes, with a host...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry Vol. 72; no. 8; p. 2164
Main Authors: YAMANE, Naoe, TOZUKA, Zenzaburo, OKADA, Yasuyo, HONDA, Chie, NISHI, Yuki, TANIMOTO, Toshiko
Format: Journal Article
Language:English
Published: Tokyo Oxford University Press 01-08-2008
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Summary:Mass spectral measurements by electrospray ionization mass spectrometry (ESI-MS) detected the ions of β-cyclodextrin (βCD) or branched βCDs (glucosyl-, galactosyl-, mannosyl- and maltosyl-βCD)-prostaglandins (PGs: PGA2, PGD2, PGE1, PGE2, PGF2α and PGJ2) complexes, i.e., βCD-PG complexes, with a host:guest ratio of 1:1 in the negative ion mode. This is the first study to report the ions of branched βCD-PG complexes using ESI-MS. The inclusion complexes were determined by a flow injection analysis using acetonitrile/water. We could confirm by this method the presence of a βCD-PGE2 complex with a host:guest ratio of 1:1 in a solution-dissolved pharmaceutical formulation consisting of βCD-PGE2 (ProstarmonTM E tablet).
ISSN:0916-8451
1347-6947