Assisted Evolution Enables HIV-1 to Overcome a High TRIM5[alpha]-Imposed Genetic Barrier to Rhesus Macaque Tropism e1003667

Diversification of antiretroviral factors during host evolution has erected formidable barriers to cross-species retrovirus transmission. This phenomenon likely protects humans from infection by many modern retroviruses, but it has also impaired the development of primate models of HIV-1 infection....

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Bibliographic Details

Published in:	PLoS pathogens Vol. 9; no. 9
Main Authors:	Soll, Steven J, Wilson, Sam J, Kutluay, Sebla B, Hatziioannou, Theodora, Bieniasz, Paul D
Format:	Journal Article
Language:	English
Published:	San Francisco Public Library of Science 01-09-2013
Subjects:	Biomedical research Evolution Infections Libraries Microbiology Mutation Proteins
Online Access:	Get full text
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