Enantiospecific Total Synthesis of (-)-BengamideE
Total synthesis of the polyhydroxy caprolactam amide natural product, bengamide E, is accomplished starting from tartaric acid. Key reactions in the synthesis include desymmetrization of the bis(dimethylamide) unit of tartaric acid, Zn(BH4)2-mediated anti-selective reduction, and a Horner-Wadsworth-...
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Published in: | Chemistry, an Asian journal Vol. 8; no. 2; p. 488 |
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Main Authors: | , , |
Format: | Journal Article |
Language: | English |
Published: |
Weinheim
Wiley Subscription Services, Inc
01-02-2013
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Subjects: | |
Online Access: | Get full text |
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Summary: | Total synthesis of the polyhydroxy caprolactam amide natural product, bengamide E, is accomplished starting from tartaric acid. Key reactions in the synthesis include desymmetrization of the bis(dimethylamide) unit of tartaric acid, Zn(BH4)2-mediated anti-selective reduction, and a Horner-Wadsworth-Emmons olefination. [PUBLICATION ABSTRACT] |
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ISSN: | 1861-4728 1861-471X |
DOI: | 10.1002/asia.201200999 |