[Beta]-Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma

Owing to its essential role in cancer, insulin-like growth factor type 1 receptor (IGF-1R)-targeted therapy is an exciting approach for cancer treatment. However, when translated into clinical trials, IGF-1R-specific antibodies did not fulfill expectations. Despite promising clinical responses in Ew...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 50; p. 20620
Main Authors:	Zheng, Huiyuan, Shen, Hongchang, Oprea, Iulian, Worrall, Claire, Stefanescu, Radu, Girnita, Ada, Girnita, Leonard
Format:	Journal Article
Language:	English
Published:	Washington National Academy of Sciences 11-12-2012
Subjects:	Cancer therapies Clinical trials Insulin-like growth factors Proteins Signal transduction Tumors
Online Access:	Get full text
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