Structure-activity relationships for inhibition of type 1 and 2 human 5α-reductase and human adrenal 3β-hydroxy-Δ5-steroid dehydrogenase/3-keto-Δ5-steroid isomerase by 6-azaandrost-4-en-3-ones : optimization of the C17 substituent

• Published in: Journal of medicinal chemistry Vol. 38; no. 14; pp. 2621 - 2627
• Main Authors: FRYE, S. V, HAFFNER, C. D, SCHWEIKER, S. L, VAN ARNOLD, J, BICKETT, D. M, MOSS, M. L, GAOCHOA TIAN, LEE, F. W, TIPPIN, T. K, JAMES, M. K, GRIZZLE, M. K, LONG, J. E, MALONEY, P. R, CROOM, D. K, HINER, R. N, DORSEY, G. F, NOE, R. A, UNWALLA, R. J, BATCHELOR, K. W, BRAMSON, H. N, STUART, J. D
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 1995
• Subjects: Analytical, structural and metabolic biochemistry; Biological and medical sciences; Enzymes and enzyme inhibitors; Fundamental and applied biological sciences. Psychology; Oxidoreductases; Prostate disease; Rat; Nitrogen heterocycle; Modeling; Isomerases; Structure activity relation; Molecular model; Dog; Fissipedia; Carnivora; Enzyme; Rodentia; Enaminone; Oral administration; Enzyme inhibitor; Tetracyclic compound; Azasteroid; In vitro; In vivo; Vertebrata; Mammalia; Animal; Carboxamide; Oxidoreductases; Pharmacokinetics
• ISSN: 0022-2623; 1520-4804