Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors

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Published in:Bioorganic & medicinal chemistry letters Vol. 19; no. 7; pp. 2048 - 2052
Main Authors: KOLTUN, Dmitry O, PARKHILL, Eric Q, MOLLOVA, Nevena, LEUNG, Kwan, CHISHOLM, Jeffrey W, ZABLOCKI, Jeff, VASILEVICH, Natalya I, GLUSHKOV, Andrei I, ZILBERSHTEIN, Timur M, IVANOV, Alexei V, COLE, Andrew G, HENDERSON, Ian, ZAUTKE, Nathan A, BRUNN, Sandra A
Format: Journal Article
Language:Russian
Published: Amsterdam Elsevier 2009
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Author PARKHILL, Eric Q
ZILBERSHTEIN, Timur M
IVANOV, Alexei V
CHISHOLM, Jeffrey W
VASILEVICH, Natalya I
ZAUTKE, Nathan A
GLUSHKOV, Andrei I
MOLLOVA, Nevena
ZABLOCKI, Jeff
BRUNN, Sandra A
COLE, Andrew G
KOLTUN, Dmitry O
LEUNG, Kwan
HENDERSON, Ian
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  givenname: Dmitry O
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  fullname: KOLTUN, Dmitry O
  organization: Department of Medicinal Chemistry, CV Therapeutics, Inc, Palo Alto, CA 94304, United States
– sequence: 2
  givenname: Eric Q
  surname: PARKHILL
  fullname: PARKHILL, Eric Q
  organization: Department of Medicinal Chemistry, CV Therapeutics, Inc, Palo Alto, CA 94304, United States
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  givenname: Nevena
  surname: MOLLOVA
  fullname: MOLLOVA, Nevena
  organization: Department of Pre-Clinical Development, CV Therapeutics, Inc, Palo Alto, CA 94304, United States
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  givenname: Kwan
  surname: LEUNG
  fullname: LEUNG, Kwan
  organization: Department of Pre-Clinical Development, CV Therapeutics, Inc, Palo Alto, CA 94304, United States
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  givenname: Jeffrey W
  surname: CHISHOLM
  fullname: CHISHOLM, Jeffrey W
  organization: Department of Pharmacological Sciences, CV Therapeutics, Inc, Palo Alto, CA 94304, United States
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  givenname: Jeff
  surname: ZABLOCKI
  fullname: ZABLOCKI, Jeff
  organization: Department of Medicinal Chemistry, CV Therapeutics, Inc, Palo Alto, CA 94304, United States
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  givenname: Natalya I
  surname: VASILEVICH
  fullname: VASILEVICH, Natalya I
  organization: ASINEX Ltd, Moscow 123367, Russian Federation
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  givenname: Andrei I
  surname: GLUSHKOV
  fullname: GLUSHKOV, Andrei I
  organization: ASINEX Ltd, Moscow 123367, Russian Federation
– sequence: 9
  givenname: Timur M
  surname: ZILBERSHTEIN
  fullname: ZILBERSHTEIN, Timur M
  organization: ASINEX Ltd, Moscow 123367, Russian Federation
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  givenname: Alexei V
  surname: IVANOV
  fullname: IVANOV, Alexei V
  organization: ASINEX Ltd, Moscow 123367, Russian Federation
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  givenname: Andrew G
  surname: COLE
  fullname: COLE, Andrew G
  organization: Department of Chemistry, Ligand Pharmaceuticals, Inc, Cranbury, NJ 08512, United States
– sequence: 12
  givenname: Ian
  surname: HENDERSON
  fullname: HENDERSON, Ian
  organization: Department of Chemistry, Ligand Pharmaceuticals, Inc, Cranbury, NJ 08512, United States
– sequence: 13
  givenname: Nathan A
  surname: ZAUTKE
  fullname: ZAUTKE, Nathan A
  organization: Department of Pharmacological Sciences, CV Therapeutics, Inc, Palo Alto, CA 94304, United States
– sequence: 14
  givenname: Sandra A
  surname: BRUNN
  fullname: BRUNN, Sandra A
  organization: Department of Pharmacological Sciences, CV Therapeutics, Inc, Palo Alto, CA 94304, United States
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Title Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors
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