Modification of estrone at the 6, 16, and 17 positions : Novel potent inhibitors of 17/?-hydroxysteroid dehydrogenase type 1

Modification of estrone at the 6, 16, and 17 positions : Novel potent inhibitors of 17/?-hydroxysteroid dehydrogenase type 1

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Bibliographic Details
Published in:Journal of medicinal chemistry Vol. 49; no. 4; pp. 1325 - 1345
Main Authors: ALLAN, Gillian M, LAWRENCE, Harshani R, MAHON, Mary F, REED, Michael J, POTTER, Barry V. L, CORNET, Josephine, BUBERT, Christian, FISCHER, Delphine S, VICKER, Nigel, SMITH, Andrew, TUTILL, Helena J, PUROHIT, Atul, DAY, Joanna M
Format: Journal Article
Language:English
Published: Washington, DC American Chemical Society 2006
Subjects:
Antineoplastic agents
Biological and medical sciences
General aspects
Medical sciences
Pharmacology. Drug treatments
Steroid
Enzyme
Nitrogen heterocycle
Isozyme
Prediction
Combinatorial chemistry
Enzyme inhibitor
Oxime
Selectivity
In vitro
Modeling
Estrane derivatives
Comparative molecular similarity indices analysis method
Structure activity relation
Carboxylic acid
Chemical compound library
Molecular model
3(or 17)β-Hydroxysteroid dehydrogenase
Carboxamide
Estrone
Aromatic compound
Oxidoreductases
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ISSN:0022-2623
1520-4804