Structure-activity relationships of the p38a MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphtha len-1-yl]urea (BIRB 796)

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Bibliographic Details
Published in:	Journal of medicinal chemistry Vol. 46; no. 22; pp. 4676 - 4686
Main Authors:	REGAN, John, CAPOLINO, Alison, PARGELLIS, Christopher A, SWINAMER, Alan, TORCELLINI, Carol, TSANG, Michele, MOSS, Neil, CIRILLO, Pier F, GILMORE, Thomas, GRAHAM, Anne G, HICKEY, Eugene, KROE, Rachel R, MADWED, Jeffrey, MORIAK, Monica, NELSON, Richard
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 2003
Subjects:	Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Medical sciences Pharmacology. Drug treatments Imidazole derivatives Morpholine derivatives Pyridine derivatives Structure activity relation Pyrazole derivatives Inhibition Chemical synthesis Tumor necrosis factor α Human Enzyme Transferases Rodentia Antiinflammatory agent Cytokine Oral administration Enzyme inhibitor Mitogen-activated protein kinase Aminoether Inflammation In vitro Naphthalene derivatives Immunomodulator Whole blood In vivo Vertebrata Chemotherapy Mammalia Treatment Mouse Protein kinase Animal
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ISSN:	0022-2623 1520-4804