Plasma leptinconcentrationsaregreaterintypeIIdiabeticpatientsand stimulatemonocytechemotacticpeptide-1synthesisviathemitogen-activatedproteinkinase/extracellularsignal-regulatedkinasepathway
Background: Leptin isanadipokinethatisrecentlyreportedtobeabiomarkerof systemic inflammation.Althoughatherosclerosiscausescardiovasculardiseases,it is notclearwhetherleptincontributestotheaccelerationofthisprocess.Inthis study, weinvestigatedwhetheralterationsofplasmaleptinlevelswererelatedto diabet...
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| Published in: | Kidney research and clinical practice pp. 177 - 185 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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대한신장학회
01-09-2012
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| Abstract | Background: Leptin isanadipokinethatisrecentlyreportedtobeabiomarkerof systemic inflammation.Althoughatherosclerosiscausescardiovasculardiseases,it is notclearwhetherleptincontributestotheaccelerationofthisprocess.Inthis study, weinvestigatedwhetheralterationsofplasmaleptinlevelswererelatedto diabetic nephropathyandsystemicinflammation.Inaddition,weexaminedthe physiologic actionofleptininculturedvascularsmoothmusclecells(VSMCs).
Methods: A totalof126type2diabeticparticipantsand37healthycontrolswere studied. Thediabeticparticipantsweredividedintothreegroupsaccordingto stage ofnephropathy.Weinvestigatedwhetherleptininducedmonocytechemo-tactic peptide-1(MCP-1)synthesisthroughthemitogen-activatedproteinkinase (MAPK) pathwayusingculturedVSMCs.
Results: Plasma leptinconcentrationsweresignificantlyhigherinthediabetic group thaninthecontrols.Plasmaleptinlevelswerepositivelycorrelatedwith body massindex,fastingandpostprandialbloodglucose,hemoglobinA1c,total cholesterol, urinaryalbuminexcretion,high-sensitivityC-reactiveprotein(hsCRP),and MCP-1plasmalevels,andnegativelycorrelatedwithcreatinineclearance values. InculturedVSMCs,leptinincreasedMCP-1productioninadose-dependent manner, andthisstimulatingeffectofleptinonMCP-1expressionwasreversedby the MAPK(MEK)inhibitorPD98059.Inaddition,leptinstimulatedthephosphor-ylation ofMEK,extracellularsignal–regulatedkinase,andE26-liketranscription factor, whicharecomponentsoftheMAPKpathway.
Conclusions: Overall, thesefindingssuggestthatactivationofleptinsynthesis may promoteMCP-1activationinadiabeticenvironmentviatheMAPKpathway in VSMCsandthatitpossiblycontributestotheaccelerationofatherosclerosis. KCI Citation Count: 1 |
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| AbstractList | Background: Leptin isanadipokinethatisrecentlyreportedtobeabiomarkerof systemic inflammation.Althoughatherosclerosiscausescardiovasculardiseases,it is notclearwhetherleptincontributestotheaccelerationofthisprocess.Inthis study, weinvestigatedwhetheralterationsofplasmaleptinlevelswererelatedto diabetic nephropathyandsystemicinflammation.Inaddition,weexaminedthe physiologic actionofleptininculturedvascularsmoothmusclecells(VSMCs).
Methods: A totalof126type2diabeticparticipantsand37healthycontrolswere studied. Thediabeticparticipantsweredividedintothreegroupsaccordingto stage ofnephropathy.Weinvestigatedwhetherleptininducedmonocytechemo-tactic peptide-1(MCP-1)synthesisthroughthemitogen-activatedproteinkinase (MAPK) pathwayusingculturedVSMCs.
Results: Plasma leptinconcentrationsweresignificantlyhigherinthediabetic group thaninthecontrols.Plasmaleptinlevelswerepositivelycorrelatedwith body massindex,fastingandpostprandialbloodglucose,hemoglobinA1c,total cholesterol, urinaryalbuminexcretion,high-sensitivityC-reactiveprotein(hsCRP),and MCP-1plasmalevels,andnegativelycorrelatedwithcreatinineclearance values. InculturedVSMCs,leptinincreasedMCP-1productioninadose-dependent manner, andthisstimulatingeffectofleptinonMCP-1expressionwasreversedby the MAPK(MEK)inhibitorPD98059.Inaddition,leptinstimulatedthephosphor-ylation ofMEK,extracellularsignal–regulatedkinase,andE26-liketranscription factor, whicharecomponentsoftheMAPKpathway.
Conclusions: Overall, thesefindingssuggestthatactivationofleptinsynthesis may promoteMCP-1activationinadiabeticenvironmentviatheMAPKpathway in VSMCsandthatitpossiblycontributestotheaccelerationofatherosclerosis. KCI Citation Count: 1 |
| Author | 한상엽 Mi Jin Lee Kum Hyun Han Dae Ryong Cha Young Youl Hyun Jin JooCha 강영선 Yi Hwa Jee |
| Author_xml | – sequence: 1 fullname: Jin JooCha organization: (KoreaUniversityAnsanHospital,Ansan,Korea) – sequence: 2 fullname: Young Youl Hyun organization: (Korea University Ansan Hospital) – sequence: 3 fullname: Yi Hwa Jee organization: (Medical Research Institute, Korea University) – sequence: 4 fullname: Mi Jin Lee organization: (Korea University Ansan Hospital) – sequence: 5 fullname: Kum Hyun Han organization: (Department of Internal Medicine, Inje University Ilsan-Paik Hospital) – sequence: 6 fullname: 강영선 organization: (고려대학교) – sequence: 7 fullname: 한상엽 organization: (인제대학교) – sequence: 8 fullname: Dae Ryong Cha organization: (Department of Internal Medicine, Korea University Ansan Hospital) |
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| Title | Plasma leptinconcentrationsaregreaterintypeIIdiabeticpatientsand stimulatemonocytechemotacticpeptide-1synthesisviathemitogen-activatedproteinkinase/extracellularsignal-regulatedkinasepathway |
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