十全大補湯藥鍼液의 사람 피부아세포의 콜라게나제 활성 및 프로콜라겐 합성과 티로시나제 활성에 미치는 영향

• Published in: Journal of pharmacopuncture pp. 51 - 60
• Main Authors: 이세나, 임강현, 김명규, 김형준, 조학준, 김명희
• Format: Journal Article
• Language: English
• Published: 대한약침학회 01-03-2011
• Subjects: 한의학
• ISSN: 2093-6966; 2234-6856

Objectives: This study was designed to investigate the collagen metabolism and tyrosinase activity of Sipgeondaebo-tang Pharmacopuncture extracts (SP).
Methods : The effect of SP on type I procollagen production and collagenase activity in human normal fibroblasts HS68 after UVB (312 nm) irradiation was measured by ELISA method. The tyrosinase activity after treatment of SP was measured as well.
Results : Type I procollagen production was recovered by SP in UVB damaged HS68 cells. The increased collagenase activity after UVB damage was significantly recovered by SP. The tyrosinase activity was significantly reduced as well. However, the L-DOPA oxidation was not changed.
Conclusion : SP showed the anti-wrinkle effects and whitening effects in vitro. These results suggest that SP may be a potential pharmacopuncture as an anti-aging pharmacopuncture treatments. KCI Citation Count: 0