Effect of Geumgoeshingi-Whan Pharmacopuncture on the Blood Pressure in Spontaneously Hypertensive Rats

• Published in: Journal of pharmacopuncture pp. 37 - 42
• Main Authors: 이미선, 김성철, 이상미, Hohyn Jeong, 박만영, 김동웅, 송봉근, 이종덕, 이호섭
• Format: Journal Article
• Language: English
• Published: 대한약침학회 01-03-2013
• Subjects: 한의학
• ISSN: 2093-6966; 2234-6856
• DOI: 10.3831/KPI.2013.16.005

Objective: The aim of this experiment was to investigate the effect and the mechanism of Geumgoeshingi-whan (GGSGW) Pharmacopuncture at the acupoint GV 4 on the blood pressure in spontaneously hypertensive rats (SHR).
Methods: SHR were injected with normal saline solution (Control-SHR group)or GGSGW Pharmacopuncture (GGSGW-SHR group) at the acupoint GV 4. The systolic arterial blood pressure and renal parameters were measured for two weeks.
Results: The systolic arterial blood pressure was decreased significantly after GGSGW Pharmacopuncture at the acupoint GV 4 in SHR, followed by a significant rise in creatine clearance. The plasma levels of aldosterone were decreased significantly after GGSGW Pharmacopunctureas were the plasma levels of atrial natriuretic peptide (ANP).
Conclusion: These results suggest that the blood pressure was decreased significantly after GGSGW Pharmacopuncture at the acupoint GV 4 in SHR and that the depressor response of the blood pressure was related to decreases in the plasma levels of aldosterone and ANP. KCI Citation Count: 0