흑대두․감초 혼합추출물이 생쥐의 비장세포 및 대식세포의 활성에 미치는 영향

• Published in: 동의생리병리학회지, 23(6) pp. 1385 - 1391
• Main Authors: 서승용, 이일화, 권진, 안문생, 은재순, 방금엽
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01-12-2009
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

The purpose of this research was to investigate the effects of the extracts of Glycyrrhiza uralensis (GE) and the combined extracts of Glycine max Merr. and Glycyrrhiza uralensis (GGE) on the activity of murine splenocytes and macrophages. GE and GGE were administered orally twice a day for 7 days at the dose of 500 mg/kg. GE decreased the viability of T- and B-lymphocytes in splenocytes, but GGE increased the viability of B-lymphocytes in splenocytes. GE increased the population of B-lymphocytes in splenocytes, but decreased the population of T-lymphocytes and splenic CD4+ cells. Also, GGE decreased the population of B-lymphocytes in splenocytes, but increased the population of T-lymphocytes and splenic CD4+ cells. Furthermore, GE and GGE enhanced the phagocytic activity of peritoneal macrophages and the production of nitric oxide. These results suggest that the regulative action of immune response of GGE is more potent than their of GE. KCI Citation Count: 5