177 Lu-EDTMP radiation absorbed dose evaluation in man based on biodistribution data in Wistar rats
Skeletal metastases are common in patients suffering from various primary cancers. Radiopharmaceuticals are an effective option for bone pain palliation. In this work, the radiation absorbed dose of 177Lu-EDTMP radiopharmaceutical was estimated for adult man based on biodistribution data in Wistar r...
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| Published in: | Nuclear engineering and technology Vol. 55; no. 1; pp. 254 - 260 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | Korean |
| Published: |
2023
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Skeletal metastases are common in patients suffering from various primary cancers. Radiopharmaceuticals are an effective option for bone pain palliation. In this work, the radiation absorbed dose of 177Lu-EDTMP radiopharmaceutical was estimated for adult man based on biodistribution data in Wistar rats. The MIRD dose calculation method and the Sparks and Aydogan methodology were applied. The results shows that about 46% of injected activity is cumulated on the surface of the trabecular and cortical bones. Radiation absorbed doses of red bone marrow and osteogenic cells were estimated to about 1.1 and 6.2 mGy/MBq, respectively. The maximum administrated activity was obtained 27 MBq/kg of body weight with an effective dose of 0.23 mSv/MBq. The results were compared with other available data from literature. This study indicated that 177Lu-EDTMP provides therapeutic efficacy for achieving bone pain palliation with low undesired dose to other normal organs. |
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| Bibliography: | KISTI1.1003/JNL.JAKO202318540568914 |
| ISSN: | 1738-5733 2234-358X |