Anti-inflammatory Triterpenes and Glyceryl Glycosides from Kandelia candel (L.) Druce

• Published in: Natural product sciences Vol. 21; no. 3; pp. 150 - 154
• Main Authors: Dat, Le Duc, Thao, Nguyen Phuong, Tai, Bui Huu, Luyen, Bui Thi Thuy, Yang, Seo Young, Kim, Sohyun, Koo, Jung Eun, Koh, Young Sang, Cuong, Nguyen The, Nam, Nguyen Hoai, Thanh, Nguyen Van, Kiem, Phan Van, Minh, Chau Van, Kim, Young Ho
• Format: Journal Article
• Language: Korean
• Published: 2015
• Subjects: IL-12 p40; TNF-α; Rhizophoraceae; Kandelia candel; IL-6; Anti-inflammation
• ISSN: 1226-3907

Phytochemical investigation of Kandelia candel resulted in the isolation of six triterpenes (1 - 5) and two glyceryl glycosides (6 and 7) and their structures were determined by comparing the spectroscopic data with those of reported values. In present study, we described the inhibitory effects of fractions and isolated compounds from K. candel on pro-inflammatory cytokines (IL-12 p40, IL-6, and TNF-α) production in lipopolysaccharide (LPS) stimulated bone marrow-derived dendritic cells (BMDCs). Results indicated that compounds 3, 6, and 7 showed potent inhibition on IL-6 production (IC50 values at less than 0.5 μM, respectively). Meanwhile, compounds 6 and 7 exhibited strong inhibitory effects on the production of TNF-α (IC50 values of 1.7 ± 0.1 and 5.5 ± 0.2 μM). Compounds 1 and 3 were also showed the inhibitory effects on IL-12 p40 production (IC50 values of 8.9 ± 0.4 and 3.3 ± 0.1 μM, respectively).