Antidiabetic activity of Diospyros malabarica Kostel bark: a preliminary investigation for possible mode of action

Antidiabetic activity of Diospyros malabarica Kostel bark: a preliminary investigation for possible mode of action

The defatted methanol extract of bark of Diospyros malabarica (DM) at doses of 200 and 400 mg/kg, p.o. showed significant hypoglycemic activity on normal rats. The extract also exerted significant antihyperglycemic effect in alloxan-induced hyperglycemia and resulted in increase in plasma protein co...

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Bibliographic Details
Published in:Oriental pharmacy and experimental medicine Vol. 8; no. 3; pp. 236 - 242
Main Authors: Mondal, Susanta Kumar, Chakraborty, Goutam, Bhaumik, Uttam Kumar, Gupta, Malaya, Mazumder, Upal Kanti
Format: Journal Article
Language:Korean
Published: 2008
Subjects:
Hyperglycemia
Biochemical parameters
Diospyros malabarica
Hypoglycemia
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Summary:The defatted methanol extract of bark of Diospyros malabarica (DM) at doses of 200 and 400 mg/kg, p.o. showed significant hypoglycemic activity on normal rats. The extract also exerted significant antihyperglycemic effect in alloxan-induced hyperglycemia and resulted in increase in plasma protein content and decrease in alkaline phosphatase, cholesterol and triglyceride levels when compared with those in the diabetic control group. However there were no significant changes in body and kidney weights of the DM extract-treated animals, compared to those of the untreated diabetic rats as a control. However, the DM extract showed a potential antioxidant activity by increasing catalase activity and reducing lipid peroxidation in liver. The results demonstrate antidiabetic activity of the defatted methanol extract of DM bark.
Bibliography:KISTI1.1003/JNL.JAKO200828955288209
ISSN:1598-2386
2211-1069