Contributed Mini Review : Stathmin 1 in normal and malignant hematopoiesis

Contributed Mini Review : Stathmin 1 in normal and malignant hematopoiesis

Stathmin 1 is a microtubule destabilizer that plays an important role in cell cycle progression, segregation of chromosomes, clonogenicity, cell motility and survival. Stathmin 1 overexpression has been reported in malignant hematopoietic cells and Stathmin 1 inhibition reduces the highly proliferat...

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Bibliographic Details
Published in:BMB reports Vol. 47; no. 12; pp. 660 - 665
Main Authors: Joao Agostinho Machado Neto, Sara Teresinha Olalla Saad, Fabiola Traina
Format: Journal Article
Language:Korean
Published: 생화학분자생물학회 31-12-2014
Subjects:
Hematopoiesis
in Fig
Leukemia
OP18
Stathmin 1
STMN1
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Summary:Stathmin 1 is a microtubule destabilizer that plays an important role in cell cycle progression, segregation of chromosomes, clonogenicity, cell motility and survival. Stathmin 1 overexpression has been reported in malignant hematopoietic cells and Stathmin 1 inhibition reduces the highly proliferative potential of leukemia cell lines. However, during the differentiation of primary hematopoietic cells, Stathmin 1 expression decreases in parallel to decreases in the proliferative potential of early hematopoietic progenitors. The scope of the present review is to survey the current knowledge and highlight future perspectives for Stathmin 1 in normal and malignant hematopoiesis, with regard to the expression, function and clinical implications of this protein.
Bibliography:Korean Society for Biochemistry and Molecular Biology
ISSN:1976-6696