Amphetamine 중독에 의한 횡문근 융해 급성신부전

• Published in: Kidney research and clinical practice Vol. 19; no. 3; pp. 532 - 536
• Main Authors: 조윤숙, Yun Sook Cho, 김태형, Tae Hyung Kim, 김형완, Hyoung Wan Kim, 김봉룡, Bong Ryong Kim, 김준완, Joon Wan Kim, 박정진, Jeong Jin Park, 손인, In Sohn
• Format: Journal Article
• Language: Korean
• Published: 대한신장학회 30-05-2000
• Subjects: Amphetamine; ARF; Rhabdomyolysis
• ISSN: 2211-9132

Amphetamine toxicity is well known in western countries since several decades ago. Taken in excessive amount, amphetamine causes systemic symptoms such as hyperpyrexia, tachycardia, hyperkinesia, delirium, seizure and circulatory collapse. Acute renal failure following amphetamine ingestion is caused by the direct toxicity of the drug, circulatory collapse, coagulopathy, retroperitoneal hematoma or tubular ob-struction by rhabdomyolysis. This is a case of a am-phetamine intoxicated 41-year male patient presenting with features of acute renal failure, which is not accompanied by circulatory collapse, nor by coagulo-pathy. Muscle enzymes and bone scan findings were compatible with nontraumatic muscle injuries, and the renal pathology was tubular necrosis with specific myoglobin casts. Therefore a drug induced rhabdo-myolysis causing myoglobinuric tubular injury is highly suspected. The fact that the outcome of the renal disease itself was good despite fatal dosage of this drug is also compatible with myoglobinuric renal failures reported by foreign authors. This is probably the first reported case of acute renal failure caused by amphetamine associated rhabdomyolysis in Korea.