알콜성 간질환에서 C형 간염 바이러스 항체 ( anti-HCV ) 의 발현율

• Published in: The Korean journal of gastroenterology Vol. 24; no. 3; pp. 529 - 534
• Main Authors: 김수경, 이용규, 김현수, 배선우, 이동기, 장우익, 권상옥, 김호근, Soo Gyeong Kim, Yong Gyu Lee, Hyun Soo Kim, Scon Woo Bae, Dong Ki Lee, Woo Ik Jang, Sang Ok Kwon, Ho Keun Kim
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 01-01-1992
• Subjects: Alcoholic liver disease; Anti-HCV antibody
• ISSN: 1598-9992

Background: The present study was undertaken to determine the prevalence of hepatitis C virus antibodis and action of hepatitis C virus infection in patients with alcoholic liver disease. Methods: Alcoholic liver disease was confirmed by history of alcohol ingestion and liver biopsy. Anti-HCV antibody was assayed.by the ELISA method (Abbott). Results: The Results were as follows 1) The overall prevalence of hepatitis C virus antibodies were 5.6%(4 of 71 patients) in alcoholic liver disease.
2) Anti-HCV antibody was not found in patients with, alcoholic chronic active hepatitis. 3) In early form of alcoholic liver diseases, such as fatty liver (0/11:0%), anti-HCV antibody was not found. But, anti-HCV antibody was found only in advanced form of alcoholic liver diseases, such as alcoholic hepatitis (1/3: 33.3%), alcoholic hepatic fibrosis (2/30: 6.7%), alcoholic cirrhosis (1/18: 0. 5%). Conclusion: The association between a role in the progression of alcoholic liver disease and hepatitis C virus infection needed further case controlled studies. However, hepatitis C virus may not play a major role in the pathogenesis of alcoholic liver disease.