Tumour response following high-dose intratumoural application of Viscum album on a patient with adenoid cystic carcinoma

• Published in: BMJ Case Reports Vol. 2014
• Main Authors: Werthmann, Paul Georg, Helling, Dieter, Heusser, Peter, Kienle, Gunver Sophia
• Format: Report
• Language: English
• Published: BMJ Publishing Group Ltd 31-07-2014
• ISSN: 1757-790X
• DOI: 10.1136/bcr-2013-203180

Adenoid cystic carcinoma (ACC) is a rare type of cancer that typically originates in the salivary glands. Surgical removal can lead to functional loss and psychological distress. Viscum album extract (VAE) is a herbal remedy with dose-dependent cytotoxic, apoptogenic and immunological effects. In some case reports, tumour regression has been observed following high-dose local applications of VAE. An active 88-year-old man with fast-growing ACC of the hard palate refused surgical removal and received high-dose intratumoural injections of VAE (alone) over a 10-month period. The tumour decreased in size, softened and loosened from its surroundings. A biopsy during the course showed inflammation. The patient remained well and without functional limitations during the therapy and follow-up period (5 months). VAE produced no reported side effects. This aged patient exemplifies a satisfying course of ACC under VAE resulting in good quality of life and partial tumour regression.