Generation of large-area tunable uniform electric fields in microfluidic arrays for rapid DNA separation

Generation of large-area tunable uniform electric fields in microfluidic arrays for rapid DNA separation

Control of electric fields over large areas is crucial for the accurate delivery and manipulation of biologically important molecules in microfluidic systems. In this paper we present a novel method for generating tunable uniform electric fields over large microfluidic arrays in two dimensions, and...

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Bibliographic Details
Published in:International Electron Devices Meeting. Technical Digest (Cat. No.01CH37224) pp. 16.3.1 - 16.3.4
Main Authors: Huang, L.R., Tegenfeldt, J.O., Kraeft, J.J., Sturm, J.C., Austin, R.H., Cox, E.C.
Format: Conference Proceeding
Language:English
Published: IEEE 2001
Subjects:
Bioinformatics
Biological materials
Boundary conditions
Current
DNA
Electric potential
Electrodes
Electrokinetics
Genomics
Microfluidics
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Summary:Control of electric fields over large areas is crucial for the accurate delivery and manipulation of biologically important molecules in microfluidic systems. In this paper we present a novel method for generating tunable uniform electric fields over large microfluidic arrays in two dimensions, and its application to a microfabricated device that separates genomic DNA. The device fractionates large DNA molecules over three orders of magnitude faster than conventional methods.
ISBN:0780370503
9780780370500
DOI:10.1109/IEDM.2001.979512