Trial Of Dimethyl Sulfoxide On Systemic Tissue Damage Due To Kerosene Ingestion

• Published in: Inönü Üniversitesi Turgut Özal Tıp Merkezi dergisi Vol. 1; no. 1
• Main Authors: Aydın,N. Engin, Özgen,Ünsal, Erbilen,Mustafa, Şahin,Sabit, Turhan,İ.Oğuz
• Format: Journal Article
• Language: English
• Published: Turgut Özal Tıp Merkezi Dergisi 01-01-1994
• Subjects: Sağlık Hizmetleri; Tıp; Malatya; Türkiye; Gaz yağı; dimethyl sulfoxide; ischemic injury; dimetil sulfoksit; Kerosene ingestion; iskemik zedelenme
• ISSN: 1300-1744; 1300-1774

Oxygen-derived free radicals promote tissue injury by cumulating in ischemic sites, and it was previously reported that hypoxic tissue lesions occur secondarily to chemical pneumonia following hydrocarbon intoxication. Dimethyl sulfoxide (DA/SO) can reduce tissue damage in gastrointestinal system by its radical removing effect, but it is not known whether it is effective similarly in other systems. From this point o f view, 30 rabbits were divided equally into three groups, and kerosene and DMSO were instilled into the stomach o f the first group through an orogastric tube. The second group received only kerosene and the third group received only DA ISO by the same way as the first group. At the end o f 48 hours rabbits were sacrificed and
organs were examined histologically. Statistical analysis revealed a non-significant difference between the first and second group (p 0.05) and there was no pathological lesion in the third group. As a conclusion, DMSO is ineffective in reducing hyfx>xic tissue damage secondary to chemical pneumonia.