The Interaction between the Endothelial Cell Protein C Receptor and Protein C Is Dictated by the γ-Carboxyglutamic Acid Domain of Protein C

The endothelial cell protein C receptor (EPCR) binds to both protein C and activated protein C (APC) with similar affinity. Removal of the Gla domain of protein C results in the loss of most of the binding affinity. This observation is compatible with at least two models: 1) the Gla domain of protei...

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Bibliographic Details

Published in:	The Journal of biological chemistry Vol. 272; no. 42; p. 26279
Main Authors:	Lisa M. Regan, Jeffery S. Mollica, Alireza R. Rezaie, Charles T. Esmon
Format:	Journal Article
Language:	English
Published:	American Society for Biochemistry and Molecular Biology 17-10-1997
Online Access:	Get full text
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