Specificity of the PTB Domain of Shc for Turn-forming Pentapeptide Motifs Amino-terminal to Phosphotyrosine

Shc phosphorylation in cells following growth factor, insulin, cytokine, and lymphocyte receptor activation leads to its association with Grb2 and activation of Ras. In addition to being a cytoplasmic substrate of tyrosine kinases, Shc contains an SH2 domain and a non-SH2 phosphotyrosine binding (PT...

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Bibliographic Details

Published in:	The Journal of biological chemistry Vol. 270; no. 31; p. 18205
Main Authors:	Thomas Trb, Wonjae E. Choi, Gert Wolf, Elizabeth Ottinger, YunJun Chen, Michael Weiss, Steven E. Shoelson
Format:	Journal Article
Language:	English
Published:	American Society for Biochemistry and Molecular Biology 04-08-1995
Online Access:	Get full text
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