Correlation between Fecal Concentrations of Ciprofloxacin and Fecal Counts of Resistant Enterobacteriaceae in Piglets Treated with Ciprofloxacin: toward New Means To Control the Spread of Resistance? CIPROFLOXACIN LEVELS AND RESISTANT BACTERIA IN FECES

• Published in: Antimicrobial agents and chemotherapy Vol. 56; no. 9; pp. 4973 - 5
• Main Authors: Nguyen, Thu Thuy, Chachaty, Elisabeth, Huy, Clarisse, Cambier, Carole, de Gunzburg, Jean, Mentré, France, Andremont, Antoine
• Format: Journal Article
• Language: English
• Published: American Society for Microbiology 01-09-2012
• Subjects: Bioinformatics; Computer Science; Human health and pathology; Infectious diseases; Life Sciences; Quantitative Methods; fecal concentration; fluoroquinolone; bacterial resistance; ciprofloxacin; Enterobacteriaceae; pharmacokinetic/pharmacodynamic relationship
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.06402-11

We assessed in a piglet model the relationship between fecal ciprofloxacin concentrations and ciprofloxacin-resistant Enterobacteriaceae counts. Twenty-nine piglets were orally treated with placebo or with 1.5 or 15 mg ciprofloxacin/kg of body weight/day from day 1 (D1) to D5. Areas under the curve (AUC) of concentrations increased sharply with dose and correlated positively with AUC of resistant bacteria log counts between D1 and D9. Removing residual colonic quinolones could help to control the emergence of resistance in fecal flora.