Pharmacokinetics of propofol nanoemulsion in dogs/Farmacocinetica do propofol em nanoemulsao em caes

• Published in: Ciência rural Vol. 43; no. 8; p. 1415
• Main Authors: Luiz, Rafael Messias, Gehrcke, Martielo Ivan, de Lima, Marcos Paulo Antunes, Poli, Anicleto, de Moraes, Aury Nunes, Farias, Felipe Hertzing, Oleskovicz, Nilson
• Format: Journal Article
• Language: Spanish
• Published: Universidade Federal de Santa Maria 01-08-2013
• Subjects: Phenols; Propofol
• ISSN: 0103-8478

Propofol nanoemulsion is a new formulation consisting of nanoemulsified systems, characterized by the absence of lipid vehicle. Changes in drug vehicle may alter the pharmacokinetics and result in different distribution and elimination rates ofpropofol. The aim of this study was to evaluate the pharmacokinetics of a new oil in water propofol nanoemulsion formulation, compared to the traditional lipid emulsion. Six neutered female mixed-breed dogs were used (10.7 ± 1.5kg) in a randomized and self control trial with 30 days interval. They received both propofol formulations administered as a bolus dose of 8mg [kg.sup.-1] followed by 60 minutes continuous infusion at 0.4mg [kg.sup.-1] [min.sup.-1] rate. Arterial blood samples were collected just before induction (0), 2, 5, 10, 15, 30, and 60 minutes after the bolus dose, and after the end of the infusion at five, 10, 15, 30, 60, and 90 minutes and 2, 3, 4, 6, 10, and 24 hours. There were no significant differences in the evaluated pharmacokinetics parameters that included volume of distribution, clearance, elimination rate constant, half-life, and distribution constants, demonstrating that propofol nanoemulsion has no pharmacokinetics differences when compared to the traditional formulation.