Toxicity of dimethyl sulfoxide in healthy dogs and with chronic kidney disease/ Toxicidade do dimetilsulfoxido em caes higidos e doentes renais cronicos

• Published in: Ciência rural Vol. 43; no. 10; p. 1831
• Main Authors: Crivellent, Leandro Zuccolotto, Crivellenti, Sofia Borin, Carvalho, Marileda Bonafim
• Format: Journal Article
• Language: Spanish
• Published: Universidade Federal de Santa Maria 01-10-2013
• Subjects: Chronic kidney failure; Dimethyl sulfoxide; Dogs
• ISSN: 0103-8478

The objective of this study was to evaluate the effects of dimethyl sulfoxide (DMSO) treatment on aspects of renal function, serum profile, total blood count parameters and clinical condition of health or chronic kidney disease (CKD) dogs. The evaluations were done before, during and after the administration of DMSO 10% at a dose of 0.5g [kg.sup.-1], each 24h, for three days. DMSO resulted in some adverse effects in both healthy and CKD dogs, however the effects were more frequent and worse in CKD dogs. Despite these adverse effects, both groups don t have contraindications to use the drug in a short time. The severity of adverse effects related to the DMSO and its possible association with death in stage 4 CKD dogs, are contraindications for the drug in this group of patients. Key words: glomerular filtration rate, creatinine clearance, electrolytes fractional excretion, renal function. O objetivo do presente trabalho foi avaliar os efeitos do tratamento com dimetilsulfoxido (DMSO) sobre aspectos pertinentes a funcao renal, perfil bioquimico serico, parametros hematologicos e condicao clinica de caes sadios e de caes com doenca renal cronica (DRC). As avaliacoes foram feitas antes, durante e apos a administracao de DMSO a 10% na dose de 0,5g [kg.sup.-1], cada 24h, por tres dias. O DMSO resultou em alguns efeitos adversos nos caes sadios e tambem nos caes com DRC, nos quais os efeitos foram mais frequentes e mais graves. Apesar desses efeitos adversos, tanto em caes sadios quanto para caes com DRC 2-3, nao ha contraindicacoes para o uso do farmaco quando em curto espaco de tempo. A gravidade dos efeitos adversos relacionados ao tratamento com DMSO e possivel associacao com o obito em caes com DRC em estadio 4, constituem fatores para contraindicacao do farmaco nesse grupo de pacientes. Palavras-chave: taxa de filtracao glomerular, depuracao de creatinina, excrecao fracionada de eletrolitos, funcao renal.