Budget Impact of Belantamab Mafodotin

• Published in: ClinicoEconomics and outcomes research Vol. 13; p. 789
• Main Authors: Hogea, Cosmina, Maiese, Eric M, Gorsh, Boris, Ambavane, Apoorva, Samyshkin, Yevgeniy, Shah, Anshul, Nikolaou, Andreas, Tosh, Jonathan C, Wang, Feng
• Format: Journal Article
• Language: English
• Published: Dove Medical Press Limited 30-09-2021
• Subjects: Analysis; Antimitotic agents; Antineoplastic agents; Care and treatment; Database industry; Dexamethasone; Diseases; Economic aspects; Epidemiology; Finance; International economic relations; Medical research; Medicine, Experimental; Multiple myeloma; Relapse
• ISSN: 1178-6981; 1178-6981

Purpose: Estimate the budget impact of belantamab mafodotin (belamaf) for patients with relapsed/refractory multiple myeloma (RRMM) who have received [greater than or equal to] 4 prior therapies, including an anti-CD38 monoclonal antibody, a proteasome inhibitor, and an immunomodulatory agent. Methods: A budget impact analysis (BIA) was developed to estimate the cost difference between current (no belamaf) and projected (with belamaf) market scenarios over 3 years. Comparators were identified from a systematic literature review and included selinexor + dexamethasone or best supportive care. The number of treatment-eligible patients were estimated using an epidemiology model. Base-case analyses were conducted from a US commercial payer perspective (cost year: 2019). Model inputs included market share estimates, treatment duration, and costs of drug acquisition/administration, concomitant medications, adverse event (AE) management, treatment monitoring, and subsequent treatments based on published literature/cost databases. Budget impact, calculated as the difference in costs between current and projected scenarios over 3 years, was reported as cost per member per month (PMPM) and per member per year (PMPY). One-way sensitivity analysis assessed which key parameters most affected model outcomes. Alternative scenarios were tested (1-or 5-year time horizon; Medicare perspective; negligible cost of mental status change AE). Results: In a hypothetical commercial payer health plan with 1 million members, 33 patients were identified as treatment-eligible over 3 years. Introducing belamaf for patients with RRMM resulted in an estimated budget-neutral PMPM cost of -$0.0003 and PMPY of -$0.004, based on n=9/33 patients receiving treatment. Sensitivity analyses showed that budget impact in the base case was most sensitive to changes in treatment duration and drug acquisition costs. Base-case results were consistent across all scenarios assessed. Conclusion: BIA indicates that adoption of belamaf in this patient population would be budget neutral for a US health plan. Keywords: BCMA, belamaf, budget impact analysis, relapsed/refractory, multiple myeloma, payer