Activity of 3′-hydroxychalcone against

• Published in: Future microbiology Vol. 12; no. 13; pp. 1123 - 1134
• Main Authors: Palanco, Ana Cerrejón, Lacorte Singulani, Junya de, Costa-Orlandi, Caroline Barcelos, Gullo, Fernanda Patrícia, Strohmayer Lourencetti, Natália Manuela, Gomes, Paulo César, Ayusso, Gabriela Miranda, Dutra, Luiz Antônio, Silva Bolzani, Vanderlan da, Regasini, Luis Octávio, Soares Mendes-Giannini, Maria José, Fusco-Almeida, Ana Marisa
• Format: Journal Article
• Language: English
• Published: Future Medicine Ltd 01-10-2017
• Subjects: antifungal; biofilm; chalcone; cryptococcosis; zebrafish
• ISSN: 1746-0913; 1746-0921
• DOI: 10.2217/fmb-2017-0062

This work aimed to evaluate the activity of 3′-hydroxychalcone against
in planktonic and biofilm forms and their toxicity using alternative animal models.
Minimum inhibitory concentration and minimum fungicide concentration were determined. Biofilm formation and the susceptibility tests were performed by the 2,3-
-(2-methoxy-4-nitro-5-sulfophenyl)-5-[carbonyl(phenylamino)]-2
-tetrazolium hydroxide assay. Toxicity and efficacy were checked in
and
models.
The compound 3′-hydroxychalcone showed fungicidal activity against
in both planktonic and biofilm forms. The toxicity in zebrafish embryos revealed a low lethal concentration. In
, the compound did not show antifungal activity and larvae toxicity.
Because of the activity of 3′-hydroxychalcone against
, molecular modifications should be made to improve efficacy and to reduce toxicity
.