Single and Four-Week Repeated Oral Toxicity Study of CJ-11555 in Sprague-Dawely Rats

• Published in: Journal of toxicology and public health Vol. 20; no. 2
• Main Authors: Kim, I.H. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), E-mail: [e-mail], Kot, Krzysztof (Covance Laboratories Inc., Virginia, USA), Lee, S.H. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Choi, J.M. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Park, J.E. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Kim, D.Y. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Noh, H.J. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Kim, T.R. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Kim, Y.H. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Kim, J.W. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Chang, J.H. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea)
• Format: Journal Article
• Language: Korean
• Published: 01-06-2004
• Subjects: Approximate lethal dose; CJ-11555; DOSAGE; DOSE; DOSIFICACION; NOAEL; RAT; RATA; RATS; Single and repeated-dose toxicity; TOXICIDAD; TOXICITE; TOXICITY
• ISSN: 1226-8399

This study was to investigate single and repeated-dose toxicities of CJ-11555, an anticirrhotic agent, in Sprague-Dawley (SD) rats. In single-dose oral toxicity study, the test article were administered once by gavage to males and females at dose levels of 0 and 2,000 mg/kg. No dead animals and abnormal necropsy findings were found in control and CJ-11555 treated group. Therefore, the approximate lethal dose of CJ-11555 was considered to be higher than 2,000 mg/kg in rats. In the 4-week repeated oral toxicity study, the test article was administered once daily by gavage to male and female rats at dose levels of 0, 10, 50 and 200 mg/kg/day for 4-weeks.