MICRORNA EXPRESSION PROFILE ALTERATIONS IN MELANOMA AND MELANOMA MICROENVIRONMENT

Melanoma of the skin is considered as multiplex neoplastic system characterized by high tumor heterogeneity. MicroRNAs are a class of epigenetic regulators by which 90 % of human genome is controlled. At the present time more than 1 500 types of microRNAs is identified. Comparative analysis of micro...

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Bibliographic Details
Published in:	Sibirskiĭ onkologicheskiĭ zhurnal Vol. 1; no. 5; pp. 67 - 73
Main Authors:	A. V. Komina, M. B. Aksenenko, N. V. Palkina, S. A. Artemiev, T. G. Ruksha
Format:	Journal Article
Language:	Russian
Published:	Russian Academy of Sciences, Tomsk National Research Medical Center 01-02-2016
Subjects:	micro-rna, melanoma, microarray
Online Access:	Get full text
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Summary:	Melanoma of the skin is considered as multiplex neoplastic system characterized by high tumor heterogeneity. MicroRNAs are a class of epigenetic regulators by which 90 % of human genome is controlled. At the present time more than 1 500 types of microRNAs is identified. Comparative analysis of microRNA expression profile is performed in melanoma, melanocytic nevi and tumor microenvironment in the present study. The differences of microRNA expression levels should be under further consideration to evaluate their functional significance in melanomagenesis and possible application as melanoma prognostic and diagnostic markers.
ISSN:	1814-4861 2312-3168