Combined toxicity of Na 2EDTA and D 2O

Physicochemical and biopharmaceutical analysis of excipients doesn’t allow to characterize them as inert components of drug products. Excipients are known to exhibit their own biological activity as well as influence the activity of API and other components of the formulation (antioxidants, stabiliz...

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Bibliographic Details
Published in:	Vestnik Rossiĭskogo universiteta druzhby narodov. Serii͡a︡ Medit͡s︡ina no. 2; pp. 5 - 9
Main Authors:	T N Burdeinaya, O Y Zrelov, T V Maksimova, M A Morozova, G I Mtei, E V Uspenskaya, T V Pleteneva, A V Syroeshkin
Format:	Journal Article
Language:	English
Published:	Peoples’ Friendship University of Russia (RUDN University) 01-12-2013
Subjects:	биофармацевтический анализ вспомогательные вещества тяжелая вода
Online Access:	Get full text
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Summary:	Physicochemical and biopharmaceutical analysis of excipients doesn’t allow to characterize them as inert components of drug products. Excipients are known to exhibit their own biological activity as well as influence the activity of API and other components of the formulation (antioxidants, stabilizers, fillers, etc.). Combined biological activity of stabilizer/antioxidant — disodium ethylenediaminetetraacetate (Na 2EDTA) — and water with different ratios of hydrogen isotopes (D / H) was studied on biological models of Spirotox. It was found that with the growth of deuterium/protium ratio in water the toxicity of Na 2EDTA increased.
ISSN:	2313-0245 2313-0261