Erythrocytes and NO: the facts and hypotheses interaction, prospects for diagnosis and therapy

This review deals with the relationship between red blood cells and nitric oxide, the role of erythrocytes as participants of vasoregulation. There were the results of studies on the physiological origin of vasoactive NO under hypoxic conditions, sources of nitric oxide associated with erythrocytes....

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Bibliographic Details
Published in:	Ateroskleroz Vol. 10; no. 3; pp. 68 - 80
Main Authors:	M. V. Kruchinina, A. A. Gromov, I. O. Svetlova, V. M. Generalov, A. S. Safatov, G. A. Buryak, V. N. Kruchinin, S. V. Rykhlitsky
Format:	Journal Article
Language:	Russian
Published:	Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics 01-09-2014
Subjects:	adenosine triphosphate deformability endothelial cells nitric oxide raman-spectroscopy red blood cells the bioavailability of no vasoregulation
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Summary:	This review deals with the relationship between red blood cells and nitric oxide, the role of erythrocytes as participants of vasoregulation. There were the results of studies on the physiological origin of vasoactive NO under hypoxic conditions, sources of nitric oxide associated with erythrocytes. The data of the NO effect on the erythrocyte deformability have been analyzed. The hypothesis of insufficient NO bioavailability during blood storage caused by degenerative changes in red blood cells (increased levels of free hemoglobin and microparticles from erythrocytes) was presented. The results of evaluation of hemoglobin associated with NO by means of Raman-spectroscopy were given. Prospects have been identified in the diagnosis and therapy related to the definition and changes in levels of erythrocyte-derived NO and ATP.
ISSN:	2078-256X