Social determinants of the changing tuberculosis prevalence in Việt Nam: Analysis of population-level cross-sectional studies

• Published in: PLoS medicine Vol. 19; no. 3
• Main Authors: Nicola Foster, Hai V. Nguyen, Nhung V. Nguyen, Hoa B. Nguyen, Edine W. Tiemersma, Frank G. J. Cobelens, Matthew Quaife, Rein M. G. J. Houben
• Format: Journal Article
• Language: English
• Published: Public Library of Science (PLoS) 01-03-2022
• ISSN: 1549-1277; 1549-1676

Background An ecological relationship between economic development and reduction in tuberculosis prevalence has been observed. Between 2007 and 2017, Việt Nam experienced rapid economic development with equitable distribution of resources and a 37% reduction in tuberculosis prevalence. Analysing consecutive prevalence surveys, we examined how the reduction in tuberculosis (and subclinical tuberculosis) prevalence was concentrated between socioeconomic groups. Methods and findings We combined data from 2 nationally representative Việt Nam tuberculosis prevalence surveys with provincial-level measures of poverty. Data from 94,156 (2007) and 61,763 (2017) individuals were included. Of people with microbiologically confirmed tuberculosis, 21.6% (47/218) in 2007 and 29.0% (36/124) in 2017 had subclinical disease. We constructed an asset index using principal component analysis of consumption data. An illness concentration index was estimated to measure socioeconomic position inequality in tuberculosis prevalence. The illness concentration index changed from −0.10 (95% CI −0.08, −0.16; p = 0.003) in 2007 to 0.07 (95% CI 0.06, 0.18; p = 0.158) in 2017, indicating that tuberculosis was concentrated among the poorest households in 2007, with a shift towards more equal distribution between rich and poor households in 2017. This finding was similar for subclinical tuberculosis. We fitted multilevel models to investigate relationships between change in tuberculosis prevalence, individual risks, household socioeconomic position, and neighbourhood poverty. Controlling for provincial poverty level reduced the difference in prevalence, suggesting that changes in neighbourhood poverty contribute to the explanation of change in tuberculosis prevalence. A limitation of our study is that while tuberculosis prevalence surveys are valuable for understanding socioeconomic differences in tuberculosis prevalence in countries, given that tuberculosis is a relatively rare disease in the population studied, there is limited power to explore socioeconomic drivers. However, combining repeated cross-sectional surveys with provincial deprivation estimates during a period of remarkable economic growth provides valuable insights into the dynamics of the relationship between tuberculosis and economic development in Việt Nam. Conclusions We found that with equitable economic growth and a reduction in tuberculosis burden, tuberculosis became less concentrated among the poor in Việt Nam. Nicola Foster and colleagues examine social and economic determinants of the changing tuberculosis prevalence in Việt Nam. Author summary Why was this study done? Historically, large reductions in tuberculosis prevalence globally have been ascribed to changes in living standards, such as housing and nutrition, that come with economic development. Previous studies have shown that social protection policies (a component of economic development) may reduce tuberculosis incidence, but that such gains are dependent on the amount invested in social protection policies. However, direct evidence of the interaction between economic growth and tuberculosis burden is limited, and evidence is missing with regards to equity. What did the researchers do and find? We used data from consecutive tuberculosis prevalence surveys conducted during a time of rapid economic growth in Việt Nam to analyse the association between equitable economic development and reduction in tuberculosis prevalence. We found a significant shift in the distribution of tuberculosis from disproportionately affecting poor households towards a more equitable distribution of the reduced tuberculosis prevalence among the population, closely linked to neighbourhood poverty indicators. What do these findings mean? Our work contributes to the body of evidence of social determinants of tuberculosis prevalence. A more equitable burden of tuberculosis disease is possible in the context of rapid, and equitable, economic growth. Further work is required to understand how improvements in healthcare services contribute to or mediate the drive towards a more equitable burden of tuberculosis.