Fibroblastic connective tissue nevus in children: a case report and literature review
Objective: To analyze the clinic-pathological features, immunohistochemical phenotype and differential diagnosis of a child with fibroblastic connective tissue nevus（FCTN）. Methods: A 2-year-old girl developed bright red sclerotic plaque on her right thigh with clear boundary and irregular shape. Bi...
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| Published in: | Zhenduanxue Lilun yu Shijian Vol. 20; no. 2; pp. 190 - 194 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | Chinese |
| Published: |
Editorial Office of Journal of Diagnostics Concepts & Practice
01-04-2021
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Objective: To analyze the clinic-pathological features, immunohistochemical phenotype and differential diagnosis of a child with fibroblastic connective tissue nevus（FCTN）. Methods: A 2-year-old girl developed bright red sclerotic plaque on her right thigh with clear boundary and irregular shape. Biopsy was performed on the lesion, and the pathological tissues were stained with HE and immunohistochemistry. The immunohistochemical phenotypes for differential diagnosis were analyzed along with literature review. Results: Histologically, the lesion was composed of bundles of bland spindle cells of fibroblastic/myofibroblastic lineage irregularly branching within the reticular dermis and along fibrous septa in the subcutis, without affecting the adnexal structures. The dermal adipocytes were entrapped by tumor cells, and elastic fibers were fragmented and decreased. Immunohistochemically, cells of FCTN were positive for CD34, and weak positive for SMA（smooth muscle actin） locally, while negative for S100, des, an |
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| ISSN: | 1671-2870 |
| DOI: | 10.16150/j.1671-2870.2021.02.013 |