Triazole Fungicide Pr ungicide Prosaro EC 250 - induced Hemat o EC 250 - induced Hematologicaland ologicaland Biochemical Alterations in Male Rabbits (Oryctolagus Cuniculus)

• Published in: Journal of bioresource management Vol. 9; no. 3; pp. 93 - 99
• Main Authors: Debabsa Rafika, Khaldi Fadila, Grara Nedjoud, Bouzahouane Hana, Guezgouz Noureddine
• Format: Journal Article
• Language: English
• Published: Wright State University 01-09-2022
• Subjects: biochemical markers; hematological profiles; kidney; prosaro ec 250; rabbits
• ISSN: 2309-3854

The study aimed to evaluate the toxic effects of fungicide Prosaro 250 EC on hematological profiles and renal functional-biochemical markers, as well as blood glucose level .Twenty-four male rabbits were equally and randomly divided into control untreated group (G1) (n =6) received distilled water and standard food, and three treated groups (n=6 each) received by oral gavage Prosaro 250 EC at three doses (mg/kg body weight (bw)), 0.093 (G2), 0.186 (G3) and 0.465 mg/kg bw (G4) for 21 days .Results revealed a significant decrease in the kidney weight, and a significant increase in the levels of serum urea, uric acid, creatinine, and glucose in Prosaro treated groups compared with the control group. Moreover, Prosaro-induced hematotoxicity was evidenced by a marked decline inred blood cell counts (RBC), hemoglobin (HGH) and hematocrit (HT) levels, along with a significant increase in white blood cell (WBC) and platelet count. Thus the sub-chronic toxicity of Prosaro 250 EC is proved to induce hematological and biochemical alterations in rabbits.