The expressions of 164 histone modification enzymes in seven groups are modulated in respond to pathogenic processes of metabolic diseases, tumors and regulatory T cell differentiation

• Published in: The Journal of immunology (1950) Vol. 198; no. 1_Supplement; pp. 210 - 210.6
• Main Authors: SHAO, YING, Chernaya, Valeria, Wang, Hong, Yang, Xiao-Feng
• Format: Journal Article
• Language: English
• Published: 01-05-2017
• ISSN: 0022-1767; 1550-6606
• DOI: 10.4049/jimmunol.198.Supp.210.6

Abstract
To determine whether the expression of histone modification enzymes is regulated in physiological and pathological conditions, we took an experimental database mining approach pioneered in our labs to determine a panoramic expression profile of 164 enzymes in 19 human and 17 murine tissues. We have made the following significant findings: 1) Histone enzymes are differentially expressed in cardiovascular, immune and other tissues; 2) Our new “pyramid model” showed that heart and T cells are among a few tissues/cell types, in which enzymes mediating histone acetylation/deacetylation, histone methylation/demethylation are in the highest varieties; and 3) Histone enzymes are more downregulated than upregulated in metabolic diseases, and regulatory T cell polarization/ differentiation, but not in tumors. These results have demonstrated that histone modification enzyme expressions are modulated in different pathophysiological conditions as well as in the processes of T cell subset conversion, differentiation and polarization, which makes upregulated histone enzymes being potential novel therapeutic targets in suppressing disease activities and Treg functions.