Abstract PR13: Targeting p-TEFb as well as the EWS-ETS-specific transcriptional program in Ewing sarcoma synergistically blocks tumor growth

Introduction: Ewing sarcomas (EwS) are highly malignant bone or soft tissue tumors. Genetically, EwS are defined by balanced chromosomal EWSR1/ETS translocations, which give rise to chimeric proteins (EWSR1-ETS) that generate an oncogenic transcriptional program associated with altered epigenetic ma...

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Bibliographic Details

Published in:	Cancer research (Chicago, Ill.) Vol. 78; no. 19_Supplement; p. PR13
Main Authors:	Hensel, Tim, Giorgi, Chiara, Schmidt, Oxana, Yen, Hsi-Yu, Steiger, Katja, Fulda, Simone, Niggli, Felix K., Weigert, Wilko, Wang, Shudong, Schäfer, Beat W., Burdach, Stefan, Richter, Günther H.S.
Format:	Journal Article
Language:	English
Published:	01-10-2018
Online Access:	Get full text
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