Abstract LB095: Hybrid TCR-CAR design surpasses conventional CARs and patient-derived TCRs in targeting an ultra-low-density neoantigen

Mutation-associated neoantigens (MANAs) are exquisitely cancer-specific therapeutic targets. However, MANAs are present at ultra-low densities on the cancer cell surface (as few as 1-2 copies per cell), leading to the challenge of eliciting a sufficiently robust therapeutic effect. We combined compo...

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Bibliographic Details

Published in:	Cancer research (Chicago, Ill.) Vol. 83; no. 8_Supplement; p. LB095
Main Authors:	Mog, Brian J., DiNapoli, Sarah R., Hwang, Michael S., Nichakawade, Tushar D., Douglass, Jacqueline, Hsiue, Emily Han-Chung, Wright, Katharine M., Pearlman, Alexander H., Konig, Maximilian F., Paul, Suman, Wyhs, Nicolas, Marcou, Nikita, Glavaris, Stephanie, Ge, Jiaxin, Miller, Michelle S., Azurmendi, P. Aitana, Watson, Evangeline, Pardoll, Drew M., Gabelli, Sandra B., Bettegowda, Chetan, Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Zhou, Shibin
Format:	Journal Article
Language:	English
Published:	14-04-2023
Online Access:	Get full text
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