Abstract 617: MEK inhibitor rescued the efficacy of PD-1 blocker in STK11/LKB1 mutated colorectal cancer model

Introduction: The mechanism of action of primary resistance to PD-1 blockade is largely unknown, however STK11/LKB1 alterations have been reported to have a significant role in primary resistance to PD-1/PD-L1 axis inhibitors in KRAS-mutant lung adenocarcinoma. It is importsnt to identify treatments...

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Bibliographic Details

Published in:	Cancer research (Chicago, Ill.) Vol. 82; no. 12_Supplement; p. 617
Main Authors:	Liu, Demi X., Zhou, Jun, Nie, Chenpan, An, Annie X., Li, Henry Q.X., Wang, Jingjing
Format:	Journal Article
Language:	English
Published:	15-06-2022
Online Access:	Get full text
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