Abstract 6221: Targeting IAP in cancer: BI 891065 a potent small molecule SMAC mimetic that synergizes with immune checkpoint inhibition

Background: Engagement of Tumor Necrosis Factor-α (TNF-α) with its receptor can lead to dramatically different cellular outcomes ranging from regulating cell survival and inflammation to induction of programmed forms of cell death. A critical proximal checkpoint determining the nature of TNF-α signa...

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Bibliographic Details

Published in:	Cancer research (Chicago, Ill.) Vol. 80; no. 16_Supplement; p. 6221
Main Authors:	Aichinger, Martin, Santoro, Valeria, Slavic-Obradovic, Ksenija, Ruhland, Stefanie, Wernitznig, Andreas, Neudolt, Andrea, Schaefer, Markus, Kallenda, Sabine, Zach, Daniel, Olt, Sabine, Salomon, Carina, Rieser, Sarah, Weissenboeck, Martina, Ebner, Florian, Schlattl, Andreas, De Almeida, Melanie Talata, Langlois, Rebecca, Sykora, Martina, Reschke, Markus, Zichner, Thomas, Gerlach, Daniel, Jude, Julian, Fellner, Michaela, Scharn, Dirk, Kraut, Norbert, Moll, Juergen, Zuber, Johannes, Carotta, Sebastian, Impagnatiello, Maria Antonietta, Tontsch-Grunt, Ulrike
Format:	Journal Article
Language:	English
Published:	15-08-2020
Online Access:	Get full text
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