Abstract 4647: Mass spectrometric analysis of oncometabolite 2-hydroxyglutarate in clinical gliomas with the isocitrate dehydrogenase-1 mutation

Introduction: Mutations of the isocitrate dehydrogenase (IDH)-1/2 genes frequently occur in certain malignancies, including gliomas. Mutant IDH-1/2 proteins gain a new ability to produce oncometabolite 2-hydroxiglutarate (2HG), which results in a different clinical impact on gliomas in comparison to...

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Bibliographic Details

Published in:	Cancer research (Chicago, Ill.) Vol. 77; no. 13_Supplement; p. 4647
Main Authors:	Hayashi, Mitsuhiro, Aikawa, Hiroaki, Ohno, Makoto, Ichimura, Koichi, Matsushita, Yuko, Ohuchi, Mayu, Mizui, Mariko, Yoshida, Akihiko, Narita, Yoshitaka, Hamada, Akinobu
Format:	Journal Article
Language:	English
Published:	01-07-2017
Online Access:	Get full text
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