Abstract 3580: Discovery and SAR study of a novel and potent Itk inhibitor as a targeted therapeutic agent for T-cell lymphoma and leukemia

Abstract Itk (IL2-inducible T-cell kinase) is a non-receptor protein tyrosine kinase. It is selectively expressed in T cells, Mast cells, and NK cells. It plays an important role in T-cell maturation, proliferation, and malignancies. Using Western blotting, Itk was only detected in three T-cell lymp...

Full description

Bibliographic Details

Published in:	Cancer research (Chicago, Ill.) Vol. 71; no. 8_Supplement; p. 3580
Main Authors:	Liu, Ruiwu, Guo, Wenchang, Ma, Aihong, Sanchez, Eduardo, Wang, Yan, Li, Jixian, Xu, Chunping, Ning, Jinying, Huang, Wenzhe, Mazloom, Anisha, Song, Aimin, Lam, Kit S., Xia, Michelle, Chen, Yiyou, Kung, Hsing-Jien
Format:	Journal Article
Language:	English
Published:	15-04-2011
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!