利妥昔单抗治疗弥漫大B细胞淋巴瘤的临床观察
目的观察利妥昔单抗治疗弥漫性大B细胞淋巴瘤（DLBCL）的疗效和不良反应。方法采用R-CHOP-21方案对40例DLBCL患者进行联合化疗。结果治疗2周期后近期疗效评价,CR15例（37.5%）,PR14例（35%）,有效率（RR）为72.5%。在不良反应中,Ⅳ度皮疹和心律失常各1例。结论利妥昔单抗近期疗效好;在不良反应中,Ⅳ度皮疹和心律失常必须及时发现和治疗。...
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| Published in: | 肿瘤防治研究 Vol. 38; no. 8; pp. 947 - 949 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | Chinese |
| Published: |
2011
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | 目的观察利妥昔单抗治疗弥漫性大B细胞淋巴瘤（DLBCL）的疗效和不良反应。方法采用R-CHOP-21方案对40例DLBCL患者进行联合化疗。结果治疗2周期后近期疗效评价,CR15例（37.5%）,PR14例（35%）,有效率（RR）为72.5%。在不良反应中,Ⅳ度皮疹和心律失常各1例。结论利妥昔单抗近期疗效好;在不良反应中,Ⅳ度皮疹和心律失常必须及时发现和治疗。 |
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| Bibliography: | 42-1241/R WANG Zhi-jun,WU Yue-bing Department of Medical Oncology,Hubei Cancer Hospital,Wuhan 430079,China Rituximab; Diffuse large B-cell lymphoma; Adverse drug reaction; Skin rash Objective To observe the curative effect and drug adverse reaction of rituximab in treatment for diffuse large B-cell lymphoma（DLBCL）.Methods R-CHOP-21 regimen was employed to 40 patients with DLBCL.Results The curative effects of the short-term were 15（37.5%） cases of complete response（CR）,14（35%） cases of partial response（PR） and response rate（RR） was 72.5%. In drug adverse reactions,skin rash or cardiac rhythm of degree Ⅳ was 1 case respectively.Conclusion The rituximab showed strongly short-term effect with moderate adverse reaction degree Ⅳ of skin toxicity and cardiac rhythm had to be found early and treated immediately. |
| ISSN: | 1000-8578 |