Phospholipase gene expression during Paracoccidioides brasiliensis morphological transition and infection

Phospholipase gene expression during Paracoccidioides brasiliensis morphological transition and infection

Phospholipase is an important virulence factor for pathogenic fungi. In this study, we demonstrate the following: (i) the Paracoccidioides brasiliensis pld gene is preferentially expressed in mycelium cells, (ii) the plb1 gene is mostly up-regulated by infection after 6 h of co-infection of MH-S cel...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz Vol. 108; no. 6
Main Authors: Soares, Deyze Alencar, Oliveira, Marilia Barros, Evangelista, Adriane Feijó, Venancio, Emerson José, Andrade, Rosângela Vieira, Soares Felipe, Maria Sueli, Petrofeza, Silvana
Format: Journal Article
Language:English
Published: Fundação Oswaldo Cruz, Fiocruz 28-02-2014
Subjects:
host-pathogen interaction
Paracoccidioides brasiliensis
pathogenicity
phospholipases
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Summary:Phospholipase is an important virulence factor for pathogenic fungi. In this study, we demonstrate the following: (i) the Paracoccidioides brasiliensis pld gene is preferentially expressed in mycelium cells, (ii) the plb1 gene is mostly up-regulated by infection after 6 h of co-infection of MH-S cells or during BALB/c mice lung infection, (iii) during lung infection, plb1, plc and pld gene expression are significantly increased 6-48 h post-infection compared to 56 days after infection, strongly suggesting that phospholipases play a role in the early events of infection, but not during the chronic stages of pulmonary infection by P. brasiliensis.
ISSN:1678-8060