Molluscicidal activity of Hammada scoparia (Pomel) Iljin leaf extracts and the principal alkaloids isolated from them against Galba truncatula

• Published in: Memórias do Instituto Oswaldo Cruz Vol. 104; no. 7
• Main Authors: Mezghani-Jarraya, R, Hammami, H, Ayadi, A, Damak, M
• Format: Journal Article
• Language: English
• Published: Fundação Oswaldo Cruz, Fiocruz 09-03-2010
• Subjects: molluscicidal activity - Galba truncatula - Fasciola hepatica - Hammada scoparia - major alkaloids - N-methylisosalsoline
• ISSN: 1678-8060

The molluscicidal activity of Hammada scoparia leaf extracts and the
principal alkaloids isolated from them (carnegine and
N-methylisosalsoline) were tested against the mollusc gastropod, Galba
truncatula, the intermediate host of Fasciola hepatica in Tunisia. The
results indicated that the molluscicidal activity was correlated with
the presence of alkaloids. A significant molluscicidal value, according
to the World Health Organization, was found with the methanol extract
(LC50 = 28.93 ppm). Further fractionation of the methanolic extract led
to the isolation of two principal alkaloids: carnegine and
N-methylisosalsoline. These alkaloids are isoquinolines that have not
previously been characterised for their molluscicidal activity. The
N-methylisosalsoline possesses the highest molluscicidal activity (LC50
= 0.47 μM against G. truncatula).