Microsatellite instability is a rare phenomenon in transition from chronic to blastic phase chronic myeloid leukemia

• Published in: Turkish journal of cancer Vol. 31; no. 2; pp. 63 - 71
• Main Authors: SAKIZLI, Meral, SERCAN, H. Ogün, KIZILDAĞ, Sefa, SERCAN, Zeynep Y
• Format: Journal Article
• Language: English
• Published: Hacettepe Üniversitesi Onkoloji Enstitüsü 2001
• Subjects: Bone Marrow; DNA; Hemic and lymphatic diseases; Hemik ve lenfatik hastalıklar; Kemik iliği; Leukemia, Myeloid, Chronic; Lösemi, miyeloid, kronik; Microsatellite Repeats; Mikrosatalit tekrarları; Neoplasms; Neoplazmlar; Trinucleotide Repeats; Trinükleotid tekrarları
• ISSN: 1019-3103

Little is understood about the basic biological mechanisms that underlie the reasons for acute transformation in chronic myeloid leukaemia (CML). Previously published reports on the potential role of microsatellite instability (MSI) in the transition from chronic to blastic phase CML, are limited in number and contain controversial results. We aimed to analyse DNA of chronic phase and blastic phase archive material of 13 CML patients for genomic instability identified by the presence of MSI using D1S430, D2S123, D3S1611, D11S29, D14S65, D17S520, BAT 40 markers, the dinucleotide repeat located in ABL, and the trinucleotide repeat located in BCR. Only two out of 13 patients manifest alterations in banding patterns in two or more loci examined and presented MSI (15%). We conclude that MSI may be a late occurring but rare event in CML evolution, and in itself is far from explaining the general instability observed in CML.