Comportamiento de linfoma relacionado con VIH/SIDA en el Instituto “Pedro Kourí”. 2004-2005
Se realizó un estudio descriptivo prospectivo en 20 pacientes infectados por el virus de la inmunodeficiencia humana (VIH) ingresados en el Instituto “Pedro Kourí” con diagnóstico de linfoma. Se evaluaron todos los pacientes al inicio del diagnóstico mediante una exhaustiva historia clínica y estudi...
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| Published in: | Revista cubana de medicina tropical Vol. 58; no. 3 |
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| Format: | Journal Article |
| Language: | Portuguese Spanish |
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| Abstract | Se realizó un estudio descriptivo prospectivo en 20 pacientes infectados por el virus de la inmunodeficiencia humana (VIH) ingresados en el Instituto “Pedro Kourí” con diagnóstico de linfoma. Se evaluaron todos los pacientes al inicio del diagnóstico mediante una exhaustiva historia clínica y estudios complementarios como: hemograma completo, velocidad de sedimentación globular, conteo de linfocitos T CD4+, deshidrogenasa láctica, carga viral para VIH, citología y biopsia. De los pacientes, 85 % presentaba conteo de CD4+ por debajo de 350 células/mm³ en el momento del diagnóstico, sin embargo, solo 55 % ofrecía cargas virales por encima de 50 000 copiasp/mL. Histológicamente el subtipo que predominó fue el de células grandes difusas y la localización más frecuente extraganglionar en 70 % de los casos. Llamó la atención la asociación existente entre niveles elevados de deshidrogenasa láctica y localización extranodal del tumor. Se encontró relación estadísticamente significativa (p< 0,05) entre el estado de inmunodepresión dado por valores de CD4+ inferiores a 350 células/mm³ y estadios avanzados (estadios III y IV) de la enfermedad tumoral. |
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| AbstractList | Se realizó un estudio descriptivo prospectivo en 20 pacientes infectados por el virus de la inmunodeficiencia humana (VIH) ingresados en el Instituto “Pedro Kourí” con diagnóstico de linfoma. Se evaluaron todos los pacientes al inicio del diagnóstico mediante una exhaustiva historia clínica y estudios complementarios como: hemograma completo, velocidad de sedimentación globular, conteo de linfocitos T CD4+, deshidrogenasa láctica, carga viral para VIH, citología y biopsia. De los pacientes, 85 % presentaba conteo de CD4+ por debajo de 350 células/mm³ en el momento del diagnóstico, sin embargo, solo 55 % ofrecía cargas virales por encima de 50 000 copiasp/mL. Histológicamente el subtipo que predominó fue el de células grandes difusas y la localización más frecuente extraganglionar en 70 % de los casos. Llamó la atención la asociación existente entre niveles elevados de deshidrogenasa láctica y localización extranodal del tumor. Se encontró relación estadísticamente significativa (p< 0,05) entre el estado de inmunodepresión dado por valores de CD4+ inferiores a 350 células/mm³ y estadios avanzados (estadios III y IV) de la enfermedad tumoral. |
| Author | Rodríguez Delgado, Francisco Ortega González, Lilia María Oropesa González, Lisset Miralles Alonso, Fernando Capó de Paz, Virginia |
| AuthorAffiliation | Instituto de Medicina Tropical Pedro Kourí |
| AuthorAffiliation_xml | – name: Instituto de Medicina Tropical Pedro Kourí |
| Author_xml | – sequence: 1 givenname: Fernando surname: Miralles Alonso fullname: Miralles Alonso, Fernando organization: Instituto de Medicina Tropical Pedro Kourí – sequence: 2 givenname: Lilia María surname: Ortega González fullname: Ortega González, Lilia María – sequence: 3 givenname: Lisset surname: Oropesa González fullname: Oropesa González, Lisset – sequence: 4 givenname: Francisco surname: Rodríguez Delgado fullname: Rodríguez Delgado, Francisco – sequence: 5 givenname: Virginia surname: Capó de Paz fullname: Capó de Paz, Virginia |
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| DocumentTitleAlternate | Behaviour of HIV/AIDS-related lymphoma in “Pedro Kourí” Institute. 2004-2005 |
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| Keywords | Linfoma relacionado con VIH/SIDA HIV/AIDS-related lymphoma CD4 |
| Language | Portuguese Spanish |
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| References_xml | – volume: 5 start-page: 44 year: 2001 end-page: 51 article-title: Epidemiology of AIDS associated malignances publication-title: AIDS Rev contributor: fullname: Soler, M; Sanjose, S; Ribera, JM; Dalmaso, L; Casanova, J – volume: 98 start-page: 2339 year: 2001 end-page: 44 article-title: Changes in AIDS-related lymphoma since the era of highly active antiretroviral therapy publication-title: Blood contributor: fullname: Besson, C; Goubar, A; Gabarre, J – volume: 2 start-page: 625 year: 1996 end-page: 9 article-title: HIV viral load markers in clinical practice: recommendations of an International AIDS Society-USA Expert Panel publication-title: Nat Med contributor: fullname: Saag, MS; Holodniy, M; Kuritzkes, DR – volume: 92 start-page: 1823 issue: 22 year: 2000 end-page: 30 article-title: Highly active antiretroviral therapy and incidence of cancer in human immunodeficiency virus-infected adult publication-title: J Natl Cancer Inst – volume: 14 start-page: 2217 year: 1996 end-page: 23 article-title: Age and serum lactate dishydrogenase level are independent prognostic factors in human immunodeficiency virus related non Hodgkin’slymphoma: a single institute study of 96 patients publication-title: J Clin Oncol contributor: fullname: Vaccher, E; 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| Title | Comportamiento de linfoma relacionado con VIH/SIDA en el Instituto “Pedro Kourí”. 2004-2005 |
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