Decoupling the effect of growth factors on cell motility and growth in advancing monolayers using the fischer equation

Cell motility is an important function in wound healing and in the process leading to reepithelization and closure of the wound. The effect of epidermal growth factor (EGP) and hepatocyte growth factor (HGF) was measured on the migration speed of keratinocyte monolayers. Both EGF and HGF increased m...

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Bibliographic Details
Published in:	Annals of biomedical engineering Vol. 28; no. SUPPL. 1; pp. S - 80
Main Authors:	Baskaran, Harihara, Hamoen, Karen, Perumpanani, Abbey, Morgan, Jeffrey, Berthiaume, Francois
Format:	Journal Article
Language:	English
Published:	01-01-2000
Subjects:	Cells Density (specific gravity) Growth kinetics Numerical methods
Online Access:	Get full text
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Summary:	Cell motility is an important function in wound healing and in the process leading to reepithelization and closure of the wound. The effect of epidermal growth factor (EGP) and hepatocyte growth factor (HGF) was measured on the migration speed of keratinocyte monolayers. Both EGF and HGF increased migration speed, however, EGF mediated its effect by increasing cell motility while HGF increased both cell motility and specific growth rate. The Fischer equation was a useful tool to delineate the mechanism whereby growth factors enhance wound healing.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-2 ObjectType-Feature-1 content type line 23 SourceType-Conference Papers & Proceedings-1 ObjectType-Conference-3
ISSN:	0090-6964