Correlation between several extrinsic factors and Paraoxonase 1 activities

• Published in: Human & veterinary medicine Vol. 5; no. 3; pp. 88 - 93
• Main Authors: Ciumărnean, Lorena, Dronca, Eleonora, Coadă, Camelia A, Sâmpelean, Dorel P, Achimaş-Cadariu, Andrei
• Format: Journal Article
• Language: English
• Published: Cluj-Napoca Bioflux SRL 01-12-2013
• Subjects: Alcohol; Apolipoproteins; Atherosclerosis; Cardiovascular disease; Consumption; Diet; Enzymes; Esterase; Family medical history; Genetic factors; Hepatitis; Lipids; Liver diseases; Metabolic syndrome; Oxidative stress; Paraoxonase; Paraoxonase 1; Physical activity; Steatosis; Studies; Tobacco; Ultrasonic imaging; Ultrasound
• ISSN: 2066-7655; 2066-7663

Objective: to investigate the PON1 activity (aryl esterase, paraoxonase and lactonase) as well as the possible influence of non-genetic factors in a representative cohort of patients with steatosis. Material and methods: We enrolled 39 subjects with steatosis that were hospitalised for multidisciplinary evaluation. The control group comprised 60 subjects without steatosis present at ultrasonography. Both groups were matched for age and sex. Each study participant answered a questionnaire regarding their lifestyle, comprising questions about diet, physical activity performed, use of medications, drugs or tobacco. We determined paraoxonase activities for all subjects. Results: There were no differences regarding paraoxonase activities between patients with steatosis as compared with healthy subjects. We did not get any statistical significance in the analysis of all studied extrinsic factor in relation to paraoxonase activities. Conclusion: steatosis and diet did not influenced paraoxonase activities.