The effect of hyaluronic acid carboxymethyl cellulose on the healing of colonic anastomosis in rats

• Published in: Bratislavské lékarské listy Vol. 110; no. 4; p. 210
• Main Authors: Adas, Gokhan, Karatepe, Oguzhan, Arýkan, Soykan, Battal, Muharrem, Kemik, Ozgur, Altiok, Merih, Kamali, Gulcin, Karahan, Servet
• Format: Journal Article
• Language: English
• Published: Slovakia 2009
• Subjects: Anastomosis, Surgical; Animals; Carboxymethylcellulose Sodium; Colon - pathology; Colon - surgery; Female; Hyaluronic Acid - administration & dosage; Membranes, Artificial; Rats; Rats, Wistar; Wound Healing - drug effects
• ISSN: 0006-9248

This study demonstrates the effect of hyaluronic acid-carboxymethylcellulose on the healing of colonic anastomosis.
30 female Wistar-Albino rats were divided into three groups; control group 1 (n=10), treated with hyaluronic acid-carboxymethylcellulose, group 2 (n=8) treated with HBO and group 3 with hyaluronic acid-carboxymethylcellulose and HBO.
Bursting pressure and rupture strength were significantly higher in the group 3 compared to other two groups (p<0.05). The severity of necrosis, granulation, neovascularisation and epithelization among groups did not show any significant difference (p>0.05). But the evaluation of inflammation showed a statistical significance (p<0.001) such as as granulation (p<0.05).
This study did not detect the negative affect of seprafilm on wound healing. Combined treatment with seprafilm and HBO has a favorable therapeutic effect on the healing of ischemic colonic anastomosis (Tab. 4, Fig. 3, Ref. 15). Full Text (Free, PDF) www.bmj.sk.